RESUMO
Two new aromadendrane sesquiterpenoids, dysosesquiflorins A and B (1 and 2), were isolated from Dysoxylum densiflorum bark, and their structures were elucidated on the basis of NMR spectroscopic data. These dysosesquiflorins showed in vitro cytotoxic activity against several cancer cell lines.
Assuntos
Antineoplásicos Fitogênicos/farmacologia , Meliaceae/química , Sesquiterpenos/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Ensaios de Seleção de Medicamentos Antitumorais , Células HL-60 , Humanos , Concentração Inibidora 50 , Células MCF-7 , Estrutura Molecular , Sesquiterpenos/química , Sesquiterpenos/isolamento & purificaçãoRESUMO
A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.
Assuntos
Antimaláricos/química , Antimaláricos/farmacologia , Apocynaceae/química , Alcaloides Indólicos/química , Alcaloides Indólicos/farmacologia , Extratos Vegetais/farmacologia , Plasmodium falciparum/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Extratos Vegetais/químicaRESUMO
Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC50, 0.9, 21.7, and >50.0 µM, respectively, 2: IC50 >50.0, 15.7, and 12.4 µM, respectively).
Assuntos
Alcaloides/química , Annonaceae/química , Antineoplásicos Fitogênicos/química , Aporfinas/química , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Aporfinas/isolamento & purificação , Aporfinas/farmacologia , Linhagem Celular Tumoral , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Espectroscopia de Ressonância Magnética , Conformação Molecular , Casca de Planta/química , Caules de Planta/químicaRESUMO
Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent antiplasmodial activity against Plasmodium falciparum 3D7.
Assuntos
Antimaláricos/química , Antimaláricos/farmacologia , Apocynaceae/química , Alcaloides Indólicos/química , Alcaloides Indólicos/farmacologia , Casca de Planta/química , Plasmodium falciparum/efeitos dos fármacos , Dicroísmo Circular , Células HL-60 , Humanos , Concentração Inibidora 50 , Espectroscopia de Ressonância Magnética , Estrutura MolecularRESUMO
Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.
Assuntos
Limoninas/isolamento & purificação , Meliaceae/química , Animais , Cristalografia por Raios X , Relação Dose-Resposta a Droga , Limoninas/química , Limoninas/farmacologia , Lipopolissacarídeos/farmacologia , Malásia , Camundongos , Modelos Moleculares , Estrutura Molecular , Óxido Nítrico/antagonistas & inibidores , Ressonância Magnética Nuclear Biomolecular , Casca de Planta/química , ômega-N-Metilarginina/farmacologiaRESUMO
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.
Assuntos
Alcaloides/isolamento & purificação , Compostos Azabicíclicos/isolamento & purificação , Alcaloides/química , Alcaloides/farmacologia , Compostos Azabicíclicos/química , Compostos Azabicíclicos/farmacologia , Relação Dose-Resposta a Droga , Alcaloides Indólicos/química , Alcaloides Indólicos/isolamento & purificação , Alcaloides Indólicos/farmacologia , Malásia , Estrutura Molecular , Óxido Nítrico Sintase Tipo II/efeitos dos fármacos , Óxido Nítrico Sintase Tipo II/metabolismo , Ressonância Magnética Nuclear Biomolecular , Casca de Planta/químicaRESUMO
Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.
Assuntos
Alcaloides/química , Aorta/efeitos dos fármacos , Apocynaceae/química , Alcaloides Indólicos/química , Casca de Planta/química , Vasodilatadores/química , Animais , Aorta/citologia , Apocynaceae/classificação , Células Cultivadas , Dicroísmo Circular , Alcaloides Indólicos/isolamento & purificação , Alcaloides Indólicos/farmacologia , Espectroscopia de Ressonância Magnética , Malásia , Masculino , Modelos Moleculares , Estrutura Molecular , Técnicas de Cultura de Órgãos , Plantas Medicinais/química , Ratos , Ratos Wistar , Estereoisomerismo , Vasodilatadores/isolamento & purificação , Vasodilatadores/farmacologiaRESUMO
A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.
Assuntos
Apocynaceae/química , Alcaloides Indólicos/isolamento & purificação , Linhagem Celular Tumoral , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Alcaloides Indólicos/química , Alcaloides Indólicos/farmacologia , Espectroscopia de Ressonância Magnética , Modelos MolecularesRESUMO
A new bisindole alkaloid, bisnicalaterine A (1), consisting of two vobasine-type skeletons, and 3-epivobasinol (2) and 3-O-methylepivobasinol (3), with vobasine-type skeletons, were isolated from the leaves of Hunteria zeylanica, and their structures were elucidated on the basis of spectroscopic data and chemical correlation. Bisnicalaterine A showed moderate cytotoxicity against various human cancer cell lines.
